In the present work, fast disintegrating tablets of Caffeine were prepared by subliming method with a view to enhance patient compliance. Initially solid dispersion of caffeine was prepared by using beta cyclodextrin. two super-disintegrants, viz., Hibiscus rosa mucilage powder and linseed mucilage powder were with camphor as subliming agent. The prepared batches of tablets were evaluated for thickness, weight variation, hardness, friability, drug content uniformity, wetting time, in-vitro disintegration time and in-vitro drug release. Six formulations with two different individual super disintegrants were tested for the in-vitro drug release pattern (in pH 6.8 phosphate buffer). Among the six promising formulations with two different individual super disintegrants the formulation F3 prepared by using 15mg of hibiscus rosa and 30 mg of camphor emerged as the best formulation when compared with formulation containing linseed mucilage powder based on the in-vitro drug release characteristics.
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